New HRPP Manual Section: Use of a Single IRB

The Final NIH Policy on Use of a Single IRB for Multi-Site Research establishes the expectation that all domestic sites participating in multi-site studies involving non-exempt human subjects research funded by NIH will use a single Institutional Review Board (sIRB) (NOT-OD-16-094). The new HRPP Manual Section, 2-2-F-iii, Use of a Single IRB (U.S. Department of Health and Human Services, National Institutes of Health), provides MSU requirements related to the selection of the sIRB and costs.

The new HRPP Manual Section is available at:

To learn more about use of a Single IRB, visit